Mersana shows that B7-H4 expression matters
The latest B7-H4 ADC shows activity only in biomarker-positive patients.
The latest B7-H4 ADC shows activity only in biomarker-positive patients.
The company is to start a first-line phase 3 breast cancer trial of gedatolisib, as second-line data approach.
But the timeline for a US green light is less clear, and the group has a cash crisis.
Two masked bispecific antibodies, licensed for $100m, produce promising early data.
Olema will soon enter the clinic, and Pfizer could shortly be in phase 3.
But, like Merck two weeks ago, GSK has failed to hit overall survival.
Data deteriorate, leaving cash-strapped Affimed relying on a post-hoc analysis and higher dosing.