If Pfizer hands back the estrogen receptor degrader, Arvinas will seek a new partner.

Weeks after criticising the group’s big pharma partner, John Houston is on his way out.

Any hopes of differentiation could come down to side effects.

Conference activity picks up, with the big one – ASCO – at the end of the month.

Arvinas and Pfizer abandon first-line atirmociclib combo plans only disclosed in January.

The company is stepping back in second-line breast cancer.

The Pfizer-partnered vepdegestrant shows a benefit in ESR1 mutants, but not in all-comers.

Giredestrant will soon become the first oral SERD to yield first-line data.

But this adds another complexity, and has camizestrant really scored a first-line win?

Approval decisions await Ono and SpringWorks, while key data approach for Pfizer and Arvinas’s SERD.