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ESMO 2024 – Opdualag comes under fire

Relativity-104 is revealed as a failure, and the phase 3 it just spawned could fail too.

ESMO 2024 – Nuvalent looks beyond its late-line Alkove

Efficacy with the group’s next-gen ALK and ROS1 inhibitors holds up, and first-line use could beckon.

ESMO 2024 – degraders disappoint again

Prelude’s SMARCA2 project and C4’s BRAF hopeful look lacklustre.

ESMO 2024 – Bristol heads for phase 3 in small-cell

Backed by a slender survival signal the industry’s only anti-fucosyl-GM1 MAb is to go pivotal.

ESMO 2024 preview – Summit could take on Merck in breast cancer

Early data suggest that PD-(L)1 x VEGF bispecifics might challenge Keytruda in triple-negative disease.

One ricochet of the ivonescimab bullet

The small cap biotech Instil Bio tries to follow in Summit’s slipstream.

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