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New phase 1 projects enter hot fields

Analysis of industry assets newly into human trials reveals three Car-T therapies and some familiar targets.

Sana regains some of its shine

The first case reports with the group’s lead Car-T therapy, plus talk of autoimmune diseases and diabetes, prompt a 39% share price surge.

Cell cycle niche seeks clinical validation

Several companies have followed Pfizer into CDK2 inhibitor development, but the jury is out on this field’s promise.

Merck’s latest move is in bispecifics

A $680m swoop for Harpoon will fill a hole in Merck’s pipeline.

J&J deal cements Ambrx’s transformation

Ambrx’s PSMA-targeting ADC generated puzzling data at ESMO, but J&J has seen enough to launch a premium-priced buyout.

Two allogeneic cell therapy switches in a day

Allogene joins Adicet in going back to the drawing board and scrapping trials in late-line aggressive lymphoma.

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