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A new order in BTK inhibition

Imbruvica faces challenges on multiple fronts.

Cubes with question marks on against blue background
Interview – Kura’s combo test nears

Can a combination approach improve the efficacy of ziftomenib in AML patients with KMT2A rearrangements?

Merck’s conjugates dominate pivotal trial initiations

Raludotatug deruxtecan, ABBV-383 and zongertinib advance into phase 3, while other pivotal programmes are expanded.

Healthcare worker with vial and needle vaccine
Interview – Gritstone hopes to inject some interest

As a key mid-stage readout approaches for the group’s neoantigen immunotherapy, Gritstone still has much to prove.

Another setback for Opdualag's post-melanoma plan

The latest failure, in colorectal cancer, follows a recent disappointment in second-line liver.

Point’s big Splash falls short

Crossover hits overall survival, pouring doubts on the group’s deal hopes.

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