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A trio of new pivotal trial entries

AstraZeneca and Lilly put PARP1 and KRAS G12C inhibitors into their first phase 3s, while Amgen advances DLL3 into early-stage disease.

Nothing like Hippo for cooling investor enthusiasm

Ikena is savaged in a bear market after reporting zero remissions in a dose-escalation trial of its lead asset.

A changing of the guard in stomach cancer?

Akeso’s cadonilimab hits in its first-line study, but there’s no US data and no US partner.

ASCO Plenary – what Astellas does Keymed might do better

Keymed’s AstraZeneca-partnered anti-Claudin18.2 ADC looks better than Astellas’s zolbetuximab – albeit on an extremely unreliable metric.

ASCO Plenary – Gilead and Arcus pedal hard with TIGIT

A domvanalimab triplet shows some promise in high PD-L1-expressing gastric cancer patients, but caveats abound.

Man in suit behind chessboard
CTOS 2023 – IDRx looks to outdo Deciphera

A 14% ORR with IDRX-42 in fourth-line GIST looks better than the 9% previously seen with Qinlock.

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