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After failing to get Seagen Merck turns to Daiichi

In paying $5.5bn for immediate rights to three Daiichi Sankyo assets Merck & Co has made its biggest bet on ADCs to date.

ESMO 2023 – butterflies for J&J

Rybrevant underwhelms in Mariposa, handing a possible advantage back to AstraZeneca’s Tagrisso.

Elevators at ESMO conference
ESMO 2023 – tarlatamab hits the target for Amgen

But late-breaking data raise questions about lack of a dose response.

ESMO 2023 – Lumakras still looks like a colorectal also-ran

And first data with a low dose are particularly unimpressive.

ESMO 2023 – some Tropion fears allayed

However, lack of meaningful efficacy in Tropion-Lung01 suggests that datopotamab deruxtecan might be restricted to a histology-defined NSCLC subgroup.

Red tap leaking water onto snow
ESMO 2023 – Pluvicto’s big splash gets an early preview

Leaked data ahead of the ESMO late breaker show a progression-free survival benefit that looks practice-changing.

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