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A flurry of first-in-human trial initiations

Projects from Affini-T, Bolt, Chimeric and Alentis, all hitting novel targets, as well as one from A2 using an old one, are set for first clinical trial entry.

Another twist in Cardiff’s onvansertib plan

Front-line phase 3 plans take shape, as the company claims a new success, this time in pancreatic cancer.

Bridge mirrors Black Diamond and Blueprint’s search for something better

The companies have all switched to improved fourth-generation EGFR projects in lung cancer, a fact that likely shows how competitive this field has become.

Approval milestones – Hutchmed, SpringWorks, Crispr and Ionis eye firsts

A work-stretched US FDA has several key approval application still to review by the end of 2023.

Astra works to avoid a datopotamab double dip

As Tropion-Breast01 is toplined positive Astra ensures the markets know that overall survival isn’t a washout.

Novartis goes 0 for 2 in PD-1 blockade

BeiGene regains rights to tislelizumab as another oncology asset blows up for Novartis.

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