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Novartis trips over the Hippo

The company discontinues its Yap/TEAD inhibitor IAG933 due to lack of tolerability and efficacy.

Triple meeting 2025 – early efficacy signs for Quanta

The G12D-preferring QTX3034 has produced responses in endometrial and colorectal cancers.  

Triple meeting 2025 – Halda’s proximity play in prostate

Early data with the RIPTAC HLD-0915 look competitive.

Triple meeting 2025 – Zai discloses pivotal DLL3 plans

An upcoming second-line SCLC phase 3 will include Imdelltra as a control option.

Tango waltzes towards phase 3

The company plans a pivotal pancreatic cancer trial after seeing two responses in eight patients.

A cautionary tale for clinical trial collaborators

AstraZeneca ended a tie-up with Asher, and then set off on its own.