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Car-T comes full circle

Bristol renews its focus on chronic lymphocytic leukaemia, but rivals haven’t fared so well here.

Merck KGaA’s oncology catalyst approaches

Three years after licensing in the IAP inhibitor xevinapant Merck KGaA will find out if the deal was worth it.

New phase 1 projects enter hot fields

Analysis of industry assets newly into human trials reveals three Car-T therapies and some familiar targets.

Sana regains some of its shine

The first case reports with the group’s lead Car-T therapy, plus talk of autoimmune diseases and diabetes, prompt a 39% share price surge.

Cell cycle niche seeks clinical validation

Several companies have followed Pfizer into CDK2 inhibitor development, but the jury is out on this field’s promise.

J&J deal cements Ambrx’s transformation

Ambrx’s PSMA-targeting ADC generated puzzling data at ESMO, but J&J has seen enough to launch a premium-priced buyout.

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