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1. ASCO-GI – Jacobio’s KRAS looks competitive in pancreatic

   … cancer with its multi-RAS inhibitor RMC-6236 at ESMO 2023; however, this study excluded G12C mutants. …

   
    

   Madeleine Armstrong
    
   - 01/18/2024 - 14:56

2. ASCO-GU preview: showdown for Exelixis

   … in neuroendocrine prostate cancer 121 Had data at ESMO 2023; company sold to Merck & Co Keynote-564 …

   
    

   Jacob Plieth
    
   - 01/25/2024 - 10:22

3. Cell cycle niche seeks clinical validation

   … +/- platinum chemo, started Aug 2023; preclinical data at ESMO 2023 AZD8421 AstraZeneca Cycad-1 trial …

   
    

   Jacob Plieth
    
   - 01/12/2024 - 17:23

4. J&J deal cements Ambrx’s transformation

   … cohorts 4-8 the confirmed ORR was 22%.   Source: ESMO 2023.   Any lingering doubts now become …

   
    

   Jacob Plieth
    
   - 01/10/2024 - 14:31

5. Merck’s latest move is in bispecifics

   … toxicity.  In a phase 1/2 study presented at ESMO 2023 HPN328 produced a confirmed response rate of 32% … house Ph1 +/- Keytruda in solid tumours ; data at ESMO 2023 Not yet given Source: Mizuho note, …

   
    

   Madeleine Armstrong
    
   - 06/19/2024 - 16:48

6. ASCO-GI preview: notable late-breakers

   … 604 KRAS G12C inhibitor with solid tumour data at ESMO 2023 Defiance Leap Therapeutics DKN-01 + …

   
    

   Jacob Plieth
    
   - 01/09/2024 - 11:43

7. Merck KGaA takes a punt on Inspirna’s novel approach

   … with ompenaclid in second-line CRC Source: ESMO 2023.   By way of benchmarks, Folfiri chemo …

   
    

   Madeleine Armstrong
    
   - 01/05/2024 - 13:36

8. Bristol makes its radiopharma move

   … data are expected late 2025 or early 2026 . At ESMO 2023, phase 1b data from that study found a 29% overall …

   
    

   Madeleine Armstrong
    
   - 01/03/2024 - 17:27

9. More warnings signs for ATR inhibition

   … ph1/2 +/- gemcitabine/irinotecan in solid tumours at ESMO 2023 IMP9064 Impact Therapeutics First data from ph1/2 +/- senaparib in solid tumours at ESMO 2023 Camonsertib Roche (licensed from Repare) …

   
    

   Madeleine Armstrong
    
   - 11/14/2023 - 10:58

10. ESMO 2023 movers – who won and who lost?

    ESMO 2023 movers – who won and who lost? …

    
     

    Jacob Plieth
     
    - 12/14/2023 - 11:53