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Actithera hopes to do FAP differently

The growing field of radiopharmaceuticals targeting fibroblast activation protein (FAP) has a new player in Actithera, a private start-up that this week tapped venture capitalists for $75.5m in a series A financing round. The company, based in the US and Norway, was founded in 2021, and claims to have a pipeline of preclinical assets, but the only one whose target is disclosed hits FAP. The most advanced radiopharmaceutical players here are Novartis, with an asset acquired from the now bankrupt Clovis, and Perspective Therapeutics, while a flurry of recent first-time entrants has seen Philogen's OncoFAP-23, Chengdu New's NRT6020 and Jiangsu HengRui's HRS-6768 enter phase 1 trials. However, Actithera wants to do things differently; it says achieving a short half-life to limit toxicity and long tumour retention to boost efficacy has proved elusive when targeting FAP, but reckons its focus on using a different linker, and especially on forming a permanent, covalent bond with FAP, will give it a better chance than others. One project that fell by the wayside is PNT6555, derived from Lilly's $1.4bn acquisition of Point Biopharma; a phase 1 trial of this has been terminated in favour of next-generation assets.

 

Selected radiopharmaceuticals targeting FAP

ProjectRadioisotopeCompanyStatus
FAP-2286Lutetium-177 (Actinium-225 in preclinical)Novartis (ex Clovis)Ph1/2 Lumiere trial in solid tumours
PSV359Lead-212Perspective TherapeuticsPh1/2 trial in solid tumours
HRS-6768UndisclosedJiangsu HengRuiPh1/2 trial in solid tumours
OncoFAP-23Lutetium-177PhilogenPh1 +/- L19-IL2 in FAP+ve solid tumours
XT117Lutetium-177SinotauPh1 trial in solid tumours
NRT6020Lutetium-177Chengdu NewPh1 in FAP+ve solid tumours
JH04Lutetium-177Biovision PharmaPh1 in FAP+ve solid tumours
PNT3087, PNT3090 & PNT3106Lutetium-177Lilly (ex Point)Next-gen projects in early ph1
PNT6555Actinium-225Lilly (ex Point)Ph1 Frontier trial terminated (“business decision”)
IM-3050Lutetium-177ImmunomeIND cleared, ph1 to start H2 2025
BRP-010Lutetium-177Boomray PharmaceuticalsPreclinical
CAM-FAP-Ac-225Actinium-225 (also worked on Lutetium-177)PrecirixIND submitted Jun 2025
FAP-VG-01Lutetium-177Vitsgen TherapeuticsPreclinical cyclic radiopeptide
TLX400UndisclosedTelix (bought from German academic group)Preclinical
RXM-4768Undisclosed beta emitterRefleXion Medical (ex3B Pharmaceuticals)Preclinical
UnnamedLutetium-177 or Actinium-225ActitheraPreclinical

Source: OncologyPipeline.

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