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ESMO 2024 – Keytruda/Lenvima leap... up to a point

Leap-012 delivers a technical win, but filing might hinge on overall survival and a call on toxicity.

ESMO 2024 – a role for immunotherapy in ovarian cancer

If the therapeutic window remains open, OncoC4/BioNTech’s gotistobart could hold promise.

ESMO 2024 – combos could be the way forward for CDK2

Incyte’s first substantial data with INCB123667 are eclipsed by Pfizer’s PF-07104091/atirmociclib combo.

ESMO 2024 – Opdualag comes under fire

Relativity-104 is revealed as a failure, and the phase 3 it just spawned could fail too.

ESMO 2024 – iTeos TIGIT meets its efficacy criteria

But the Galaxies Lung-201 trial features notable omissions, plus toxicity.

ESMO 2024 – Nuvalent looks beyond its late-line Alkove

Efficacy with the group’s next-gen ALK and ROS1 inhibitors holds up, and first-line use could beckon.

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