Rival BTK degraders face off in CLL patients naive to BTK inhibition.
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Talvey looks good with Darzalex in the second line, while Pomalyst’s role is less clear.
A prostate cancer project licensed from Orion enters phase 3, while pivotal trials are expanded with assets originated at Kelun and Arqule.
New clinical trial listings reveal first-in-human studies for Astra’s AZD3470, a new Car-T therapy from Caribou, a B7-H4 challenger and others.
The new deal comes as Carvykti manufacturing problems continue and 2seventy dials down Abecma expectations.
Novartis and Gracell place further bets on shortened production times, with Bristol waiting in the wings.
First-in-human clinical trial initiations include yet another KRAS G12C inhibitor, and an ADC against PD-L1.
Novartis' Jakafi faces competition from GSK's momelotinib, while Astra looks over its shoulder at Merck in biliary tract cancer.