Early data on Rybrevant plus chemo have spurred a quick leap into pivotal trials.

If the therapeutic window remains open, OncoC4/BioNTech’s gotistobart could hold promise.

Incyte’s first substantial data with INCB123667 are eclipsed by Pfizer’s PF-07104091/atirmociclib combo.

Leap-012 delivers a technical win, but filing might hinge on overall survival and a call on toxicity.

Relativity-104 is revealed as a failure, and the phase 3 it just spawned could fail too.

But the Galaxies Lung-201 trial features notable omissions, plus toxicity.

Efficacy with the group’s next-gen ALK and ROS1 inhibitors holds up, and first-line use could beckon.

The group’s B7-H3 ADC looks competitive versus rival projects from Merck/Daiichi and GSK/Hansoh.

The company’s HIF-2α inhibitor impresses on efficacy, but its long half life raises eyebrows.