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FDA red and green lights: April 2025

April saw a checkpoint inhibitor bonanza for Bristol and Akeso.

AACR 2025 – a requiem for Roche's TIGIT

Survival in Skyscraper-01 deteriorated, and bore no relation to the Cityscape result.

AACR 2025 – an academic reminder about Jemperli

An MSKCC study continues to show a 100% response rate in pre-operative rectal cancer.

AACR 2025 – BioNTech sees its first combo glimmers

A BNT327 and BNT325 combo shows promise in platinum-resistant ovarian cancer.

Astra stumbles again with Truqap

The CAPItello-280 castrate-resistant prostate cancer trial is discontinued early.

Unharmonious ivonescimab reveal for Summit

The same trial that sent Summit up 272% sees the stock crash 36%.